The Limitations and Promise of Immunotherapy With Chimeric Antigen–Modified T Cells

The use of chimeric antigen receptor (CAR)-modified T cells is a promising antineoplastic immunotherapy. As discussed by Drs. Frey and Porter in this issue of ONCOLOGY,[1] it involves genetic manipulation of autologous cytotoxic T cells to create a product capable of targeting specific tumor antigens. (more…)